People feel that their lives are more meaningful while engaging in behaviors more closely aligned with their routines. Does the behavioral content of these routines and the contextual factors surrounding their enactment matter for this relationship? In two experience sampling studies (N = 93, 1,512 episodes; N = 97, 1,629 episodes), we test whether the relationship between routines and meaning in life (MIL) depends on the content of the activities. We found that the degree to which one’s current activity is a routine positively related to momentary MIL beyond other meaningful features (e.g., relationships, goals, prosociality) of that activity. We conducted Study 2 in the context of mass routine disruptions of the COVID-19 pandemic. We found even stronger relationships between routine enactment and concurrent MIL in this context which held controlling for factors, including perceived chaos, mood, and anxiety. These findings suggest that routines uniquely relate to MIL, beyond the meaningfulness of their content and across contexts.